For the purpose of the curative effects of oral D-penicillamine in lead Ip0soning,D-penicillamine was orally administered to 7 lead poisoned workers which were employed in glaze product industry dealing with the lead oxide (Pb3O4).
The doses of D-penicillamine was 1, 200mg per day which was administered by oral 7days schedules, taking for 5 days and stopping for the following 2days,repeatedly´i during 3 months period-(All the poisoned workers started working again in that industry after I´ month treatment, and were treated by oral D-penicillamine for 2 months still being exposed to contaminated environment.
In order to evaluate the curative effects of D-penicillamine, IOgm of whole blood and 24 hours urine were collected every 14 days during the curative period for laboratory analysis(hemoglobin, blood lead. urine c-aminolevulinic acid, urine coproporphyrin, and urine lead levels) with the observation of the clinical symptoms.
The results were as follows;
1. Oral D-penicillamine effected good curative results as that hemoglobin, blood lead, urine caminolevulinic acid, and urine coproporphyrin levels were decreased belpiv the critical level within 1 month treatment.
2. After re-exposure, oral D-penicillamine effected to some extent as that urine lead level was i
decreased ´below the critical level after 3 months treatment with disappgarence of the clinical
symptoms after 2 months treatment. However, the curative effects of orral D-penicillamine in the lead exposure state is questionable since increasement of blood lead ´ level and remarkable decreasement of urine lead level after 3 months treatment can be observed.
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